ISSN 2286-6493
Journal of Asian Association of Schools of Pharmacy
 

Hypolipidemic Effect of the Lyophilized Fruit Pulp of Guyabano, Annona Muricata Linn. (Fam. Annonaceae) in Atherogenic Diet-Induced Hyperlipidemia in Albino Rats  Research Paper 

de La Cruz Angelica May A1, Catabay Alice P2
1 Department of Pharmacy, Mariano Marcos State University, City of Batac, 2906 Ilocos Norte, Philippines
2 Dean, College of Pharmacy, De La Salle Health Sciences Institute, Congressional Avenue, Dasmariñ
3 as, 4114 Cavite
 

Abstract

    The hypolipidemic activity of the three doses of lyophilized fruit pulp of Guyabano were evaluated in atherogenic diet-induced albino rats. Pre-test post-test experimental design was conducted by comparing the TC, TG, LDL-c, HDL-c, and AIP. Bioassay findings show that, the Guyabano fruit pulp can control, in a dose-dependent manner, the increase in TC, TG, LDL-c, AIP, and decrease in HDL-c caused by high fat and high cholesterol diet. Histopathological analysis of the liver, heart, and blood vessels also revealed that the fruit pulp was effective in curtailing the deposition of fats, implying its potential ability to prevent the occurrence of hyperlipidemia. Phytochemical screening confirmed that the fruit pulp contained condensed tannins, polyphenols, reducing sugars, fixed oils, proteins, saponins, unsaturated steroids, 2-deoxysugars and flavonoids potentially responsible for its hypolipidemic property.  



Keywords

1 Guyabano
2 High Density Lipoprotein Cholesterol
3 Low Density Lipoprotein Cholesterol
4 Total Cholesterol
5 Triglyceride



Published in

JAASP Volume 5
January - December, 2016

Page: 351-359


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