ISSN 2286-6493
Journal of Asian Association of Schools of Pharmacy

Fabrication of calcium pectinate microparticles from pomelo pectin by ionotropic gelation  Research Paper 

Pornsak Sriamornsak1,2, Srisuda Konthong2 and Jurairat Nunthanid1,2
1 Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000 Thailand.
2 Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000 Thailand.


    The aim of this study was to fabricate calcium pectinate from pomelo into microparticles by ionotropic gelation. The effect of concentrations of pectin extracted from pomelo peels on size and drug dissolution from calcium pectinate microparticles was investigated and characterized by powder X-ray diffractometry. Ibuprofen was used as a model drug. Smooth surface and spherical microparticles of calcium pectinate was observed by scanning electron microscopy. Average particle size of calcium pectinate microparticles was about 2-5 µm. An increase in pomelo pectin increased the particle size of the microparticles. An amorphous form of the microparticles with a crystalline form of the drug was obtained. Drug dissolution from the microparticles differed from intact ibuprofen. It leads to conclude that ibuprofen could be encapsulated in the microparticles fabricated from calcium pectinate from pomelo pectin using ionotropic gelation.  


1 calcium pectinate
2 microparticles
3 ionotropic gelation
4 pomelo pectin

Published in

JAASP Volume 1 No. 4
October - December, 2012

Page: 203-209

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